Related references
Note: Only part of the references are listed.Senescence and aging: Causes, consequences, and therapeutic avenues
Domhnall McHugh et al.
JOURNAL OF CELL BIOLOGY (2018)
Overexpression of PGC-1α in aging muscle enhances a subset of young-like molecular patterns
Sofia Garcia et al.
AGING CELL (2018)
Telomere uncapping and vascular aging
R. Garrett Morgan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)
Mitochondria, its DNA and telomeres in ageing and human population
Egija Zole et al.
BIOGERONTOLOGY (2018)
Structure of Telomerase with Telomeric DNA
Jiansen Jiang et al.
CELL (2018)
Stress, cell senescence and organismal ageing
Joao Pedro de Magalhaes et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2018)
TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops
Yong Woo Lee et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease
Jodie Birch et al.
PHARMACOLOGY & THERAPEUTICS (2018)
Hallmarks of Cellular Senescence
Alejandra Hernandez-Segura et al.
TRENDS IN CELL BIOLOGY (2018)
TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops
Yong Woo Lee et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis
Yanhua Kang et al.
CELL REPORTS (2018)
The twilight of immunity: emerging concepts in aging of the immune system
Janko Nikolich-Zugich
NATURE IMMUNOLOGY (2018)
Telomere Protection by TPP1/POT1 Requires Tethering to TIN2 (vol 44, pg 647, 2011)
Kaori K. Takai et al.
MOLECULAR CELL (2017)
The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Elena Anso et al.
NATURE CELL BIOLOGY (2017)
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Ok Hee Jeon et al.
NATURE MEDICINE (2017)
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Robert Hansel-Hertsch et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
Shira Sagie et al.
NATURE COMMUNICATIONS (2017)
Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
Fabian Erdel et al.
CELL REPORTS (2017)
Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres
Caitlin M. Roake et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
Chunyi Hu et al.
CELL RESEARCH (2017)
Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span
Aksinya Derevyanko et al.
AGING CELL (2017)
Sirtuins, a promising target in slowing down the ageing process
Wioleta Grabowska et al.
BIOGERONTOLOGY (2017)
TERRA RNA Antagonizes ATRX and Protects Telomeres
Hsueh-Ping Chu et al.
CELL (2017)
Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle
Marco Graf et al.
CELL (2017)
Senescence in Health and Disease
Shenghui He et al.
CELL (2017)
Telomeres and the natural lifespan limit in humans
Troels Steenstrup et al.
AGING-US (2017)
Mammalian Mitochondria and Aging: An Update
Timo E. S. Kauppila et al.
CELL METABOLISM (2017)
Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells
Bingdong Sui et al.
BIOGERONTOLOGY (2016)
Inflammation and frailty in the elderly: A systematic review and meta-analysis
Pinar Soysal et al.
AGEING RESEARCH REVIEWS (2016)
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation
Yang Wang et al.
AGING CELL (2016)
Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin
Jigar N. Bandaria et al.
CELL (2016)
From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence
Christopher D. Wiley et al.
CELL METABOLISM (2016)
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Christopher D. Wiley et al.
CELL METABOLISM (2016)
Mitochondria are required for pro-ageing features of the senescent phenotype
Clara Correia-Melo et al.
EMBO JOURNAL (2016)
TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe
Martin Moravec et al.
EMBO REPORTS (2016)
TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding (vol 57, pg 622, 2015)
Grzegorz Sarek et al.
MOLECULAR CELL (2016)
TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres
Tatsuya Kibe et al.
MOLECULAR CELL (2016)
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection
Delphine Benarroch-Popivker et al.
MOLECULAR CELL (2016)
The Mitochondrial Basis of Aging
Nuo Sun et al.
MOLECULAR CELL (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker et al.
NATURE (2016)
Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Navdeep S. Chandel et al.
NATURE CELL BIOLOGY (2016)
Stop pulling my strings - what telomeres taught us about the DNA damage response
Eros Lazzerini-Denchi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Nuclear DNA damage signalling to mitochondria in ageing
Evandro Fei Fang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
A higher-order entity formed by the flexible assembly of RAP1 with TRF2
Guillaume Gaullier et al.
NUCLEIC ACIDS RESEARCH (2016)
Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops
Anirban Kar et al.
NUCLEIC ACIDS RESEARCH (2016)
Re-evaluation of G-quadruplex propensity with G4Hunter
Amina Bedrat et al.
NUCLEIC ACIDS RESEARCH (2016)
Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis
Elisabetta Balestro et al.
PLOS ONE (2016)
Telomerase RNA is more than a DNA template
Christopher J. Webb et al.
RNA BIOLOGY (2016)
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang et al.
SCIENCE (2016)
Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells
Myung Jin Son et al.
STEM CELLS (2016)
Telomeric RNAs are essential to maintain telomeres
Juan Jose Montero et al.
NATURE COMMUNICATIONS (2016)
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
Rekha Rai et al.
NATURE COMMUNICATIONS (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
Aleksandra Dabrowska et al.
AGING-US (2015)
Safety of Metformin in Patients with Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus
Andrew W. Hitchings et al.
COPD-Journal of Chronic Obstructive Pulmonary Disease (2015)
Therapeutic effect of androgen therapy in a mouse model of aplastic anemia produced by short telomeres
Christian Baer et al.
HAEMATOLOGICA (2015)
High-throughput sequencing of DNA G-quadruplex structures in the human genome
Vicki S. Chambers et al.
NATURE BIOTECHNOLOGY (2015)
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Nicolas Herranz et al.
NATURE CELL BIOLOGY (2015)
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge et al.
NATURE CELL BIOLOGY (2015)
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Bennett G. Childs et al.
NATURE MEDICINE (2015)
TERRA and the state of the telomere
Karsten Rippe et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Complex interactions between the DNA-damage response and mammalian telomeres
Nausica Arnoult et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
G-quadruplexes and their regulatory roles in biology
Daniela Rhodes et al.
NUCLEIC ACIDS RESEARCH (2015)
Telomere dysfunction causes alveolar stem cell failure
Jonathan K. Alder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
TERT promoter mutations and telomerase reactivation in urothelial cancer
Sumit Borah et al.
SCIENCE (2015)
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
Elizabeth H. Blackburn et al.
SCIENCE (2015)
NAD+ in aging, metabolism, and neurodegeneration
Eric Verdin
SCIENCE (2015)
Telomere functions grounding on TERRA firma
Claus M. Azzalin et al.
TRENDS IN CELL BIOLOGY (2015)
An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate
Maria Maryanovich et al.
NATURE COMMUNICATIONS (2015)
Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
P. Rocheteau et al.
NATURE COMMUNICATIONS (2015)
TERRA and the state of the telomere
Karsten Rippe et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Complex interactions between the DNA-damage response and mammalian telomeres
Nausica Arnoult et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres
Amanda K. Frank et al.
PLOS GENETICS (2015)
Therapeutic effect of androgen therapy in a mouse model of aplastic anemia produced by short telomeres
Christian Baer et al.
HAEMATOLOGICA (2015)
Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
Evandro Fei Fang et al.
CELL (2014)
NAD+ Deficiency in Age-Related Mitochondrial Dysfunction
Tomas A. Prolla et al.
CELL METABOLISM (2014)
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Claudio Franceschi et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1
David Frescas et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Geriatric muscle stem cells switch reversible quiescence into senescence
Pedro Sousa-Victor et al.
NATURE (2014)
The role of senescent cells in ageing
Jan M. van Deursen
NATURE (2014)
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Benjamin D. Cosgrove et al.
NATURE MEDICINE (2014)
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
Jennifer D. Bernet et al.
NATURE MEDICINE (2014)
Metabolic requirements for the maintenance of self-renewing stem cells
Keisuke Ito et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Cellular senescence: from physiology to pathology
Daniel Munoz-Espin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Length-dependent processing of telomeres in the absence of telomerase
Emilie Fallet et al.
NUCLEIC ACIDS RESEARCH (2014)
Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase
Tai-Yuan Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
Sujay Ray et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
A systematic review of leukocyte telomere length and age in adults
Aysel Mueezzinler et al.
AGEING RESEARCH REVIEWS (2013)
The Role of Telomere Biology in Cancer
Lifeng Xu et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 8 (2013)
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
Martin Wahlestedt et al.
BLOOD (2013)
Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation
Ylli Doksani et al.
CELL (2013)
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes et al.
CELL (2013)
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Keiyo Takubo et al.
CELL STEM CELL (2013)
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
Albert R. Davalos et al.
JOURNAL OF CELL BIOLOGY (2013)
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Juan Carlos Acosta et al.
NATURE CELL BIOLOGY (2013)
Oxidized Amino Acid Residues in the Vicinity of QA and PheoD1 of the Photosystem II Reaction Center: Putative Generation Sites of Reducing-Side Reactive Oxygen Species
Laurie K. Frankel et al.
PLOS ONE (2013)
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
Darren J. Baker et al.
CELL REPORTS (2013)
A senescent cell bystander effect: senescence-induced senescence
Glyn Nelson et al.
AGING CELL (2012)
Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST
Peng Wu et al.
CELL (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
Bruno Bernardes de Jesus et al.
EMBO MOLECULAR MEDICINE (2012)
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
Jayakrishnan Nandakumar et al.
NATURE (2012)
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
Bryan A. Gibson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
Remi-Martin Laberge et al.
CANCER MICROENVIRONMENT (2012)
The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
Bruno Bernardes de Jesus et al.
AGING CELL (2011)
A positive role for c-Abl in Atm and Atr activation in DNA damage response
X. Wang et al.
CELL DEATH AND DIFFERENTIATION (2011)
Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
Michael Rera et al.
CELL METABOLISM (2011)
Telomere Protection by TPP1/POT1 Requires Tethering to TIN2
Kaori K. Takai et al.
MOLECULAR CELL (2011)
Telomere dysfunction induces metabolic and mitochondrial compromise
Erguen Sahin et al.
NATURE (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Maria M. Mihaylova et al.
NATURE CELL BIOLOGY (2011)
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
Jasmine S. Smith et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional
G. Lossaint et al.
ONCOGENE (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner
Martin J. Law et al.
CELL (2010)
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
Chrysa M. Latrick et al.
EMBO JOURNAL (2010)
Quantitative assessment of markers for cell senescence
Conor Lawless et al.
EXPERIMENTAL GERONTOLOGY (2010)
TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo
Eladio Abreu et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
Sophie Redon et al.
NUCLEIC ACIDS RESEARCH (2010)
Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging
Mary Armanios et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
Rodrigo T. Calado et al.
BLOOD (2009)
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
Agnel Sfeir et al.
CELL (2009)
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
Yuji Nakamaru et al.
FASEB JOURNAL (2009)
Interleukin-6 Maintains Bone Marrow-Derived Mesenchymal Stem Cell Stemness by an ERK1/2-Dependent Mechanism
Katie L. Pricola et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres
Zhong Deng et al.
MOLECULAR CELL (2009)
A two-step model for senescence triggered by a single critically short telomere
Pauline Abdallah et al.
NATURE CELL BIOLOGY (2009)
How Telomeres Solve the End-Protection Problem
Titia de Lange
SCIENCE (2009)
Senescence-messaging secretome: SMS-ing cellular stress
Thomas Kuilman et al.
NATURE REVIEWS CANCER (2009)
Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways
Karl E. Herbert et al.
CIRCULATION RESEARCH (2008)
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
NATURE REVIEWS CANCER (2008)
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
Stefan Schoeftner et al.
NATURE CELL BIOLOGY (2008)
Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
Claus M. Azzalin et al.
SCIENCE (2007)
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Andrew S. Brack et al.
SCIENCE (2007)
Molecular dissection of formation of senescence-associated heterochromatin foci
Rugang Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase
Huawei Xin et al.
NATURE (2007)
The POT1-TPP1 telomere complex is a telomerase processivity factor
Feng Wang et al.
NATURE (2007)
How stem cells age and why this makes us grow old
Norman E. Sharpless et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Medical progress: Hematopoietic stem-cell transplantation
EA Copelan
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Extension of G-quadruplex DNA by ciliate telomerase
L Oganesian et al.
EMBO JOURNAL (2006)
Shelterin: the protein complex that shapes and safeguards human telomeres
T de Lange
GENES & DEVELOPMENT (2005)
Effects of telomerase and telomere length on epidermal stem cell behavior
I Flores et al.
SCIENCE (2005)
Switching human telomerase on and off with hPOT1 protein in vitro
M Lei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Reactive oxygen species as mediators of cellular senescence
R Colavitti et al.
IUBMB LIFE (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
IM Conboy et al.
NATURE (2005)
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
S Parrinello et al.
JOURNAL OF CELL SCIENCE (2005)
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
C Kelleher et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Prevalence of quadruplexes in the human genome
JL Huppert et al.
NUCLEIC ACIDS RESEARCH (2005)
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
HY Cohen et al.
SCIENCE (2004)
Reversal of human cellular senescence:: roles of the p53 and p16 pathways
CM Beauséjour et al.
EMBO JOURNAL (2003)
POT1 as a terminal transducer of TRF1 telomere length control
D Loayza et al.
NATURE (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
W Zwerschke et al.
BIOCHEMICAL JOURNAL (2003)
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
C Schaffitzel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Regulation of cellular senescence by p53
K Itahana et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Control of human telomere length by TRF1 and TRF2
A Smogorzewska et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)