Journal
BIOGERONTOLOGY
Volume 16, Issue 2, Pages 133-145Publisher
SPRINGER
DOI: 10.1007/s10522-014-9498-z
Keywords
Aging; Intestine; Mucosal immune system; M cells; IgA
Categories
Funding
- Institute Strategic Programme Grant funding from the Biotechnology and Biological Sciences Research Council
- European Commission [222887]
- [BB/J014672/1]
- [BB/K021257/1]
- [BB/L007452/1]
- BBSRC [BBS/E/D/20231762, BBS/E/D/20251967, BBS/E/D/20231759, BB/K021257/1, BB/J014672/1, BB/L007452/1, BBS/E/D/20251968] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K021257/1, BB/J014672/1, BBS/E/D/20231759, BBS/E/D/20251967, BB/L007452/1, BBS/E/D/20231762, BBS/E/D/20251968] Funding Source: researchfish
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Bacterial and viral infections of the gastrointestinal tract are more common in the elderly and represent a major cause of morbidity and mortality. The mucosal immune system provides the first line of defence against pathogens acquired by ingestion and inhalation, but its function is adversely affected in the elderly. This aging-related decline in the immune function is termed immunosenescence and is associated with diminished abilities to generate protective immunity, reduced vaccine efficacy, increased incidence of cancer, inflammation and autoimmunity, and the impaired ability to generate tolerance to harmless antigens. In this review we describe our current understanding of the effects immunosenescence has on the innate and adaptive arms of the mucosal immune system in the intestine. Current estimates suggest that by the year 2050 up to 40 % of the UK population will be over 65 years old, bringing with it important health challenges. A thorough understanding of the mechanisms that contribute to the development of immunosenescence is therefore crucial to help identify novel approaches to improve mucosal immunity in the elderly.
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