Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 11, Pages 555-560Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01688-1
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Funding
- NINDS NIH HHS [NS39854, NS28828, NS11766] Funding Source: Medline
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Mitochondrial respiratory chain diseases are a highly diverse group of disorders whose main unifying characteristic is the impairment of mitochondrial function. As befits an organelle containing gene products encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), these diseases can be caused by inherited errors in either genome, but a surprising number are sporadic, and a few are even caused by environmental factors.
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