Journal
BIOGERONTOLOGY
Volume 11, Issue 1, Pages 17-30Publisher
SPRINGER
DOI: 10.1007/s10522-009-9223-5
Keywords
Antioxidants; Screening; Lifespan; Ageing; C. elegans; Free radicals; Cortex magnoliae officinalis; Curculigo orchioides Gaertn; Glycyrrhiza uralensis Fisch; Psoralea corylifolia L.; Cratoxylum cochinchinense; Pine bark
Categories
Funding
- Biomedical Research Council of Singapore [BMRC 03/ 1/ 21/ 18/ 213, BMRC 07/ 1/ 21/ 19/ 524]
Ask authors/readers for more resources
Antioxidants are often investigated as a promising strategy for extending lifespan. Accordingly, there is significant interest in novel antioxidant compounds derived from natural sources such as plant extracts. However, because lifespan studies are laborious and expensive to conduct, candidate compounds are frequently selected based simply on their in vitro antioxidant efficacy, with the implicit assumption that in vitro antioxidants are also in vivo antioxidants, and that in vivo antioxidants will decrease functionally relevant oxidative damage and thereby extend lifespan. We investigated the validity of these assumptions in the model organism, Caenorhabditis elegans. Nematodes were exposed to 6 plant extracts, selected out of a total of 34 based on a simple in vitro antioxidant assay. We found no correlation between in vitro and in vivo antioxidant capacities. Antioxidant efficacies were also not predictive of lifespan benefits. Further studies into those extracts that produced significant lifespan extension indicated that a direct antioxidant effect is unlikely to be the main factor responsible for the modulation of nematode lifespan.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available