Journal
APOPTOSIS
Volume 5, Issue 5, Pages 415-418Publisher
SPRINGER
DOI: 10.1023/A:1009616228304
Keywords
apoptosis; death receptors; inflammation; reactive oxygen species (ROS)
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Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
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