Journal
TRENDS IN BIOTECHNOLOGY
Volume 18, Issue 11, Pages 449-455Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0167-7799(00)01499-2
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New methods enable the identification of compounds that both induce a specific cellular state and lead to identification of proteins that regulate that state. Together, developments in three critical areas: chemical diversity, phenotype-based screening and target identification, enable the systematic application of this chemical genetic approach to almost any biological problem or disease process.
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