Journal
MOLECULAR MEDICINE TODAY
Volume 6, Issue 11, Pages 418-424Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1357-4310(00)01798-6
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Systemic lupus erythematosus is an autoimmune disorder that predominantly affects women during the childbearing years. Clinically, major organ systems are affected, including the skin, kidneys and nervous system. Genetic, hormonal, environmental and immunoregulatory factors contribute to the highly variable expression of the disease. Impaired cellular and humoral immune responses reflect disordered biochemical and molecular functions that might be determined genetically. Enhanced understanding of these molecular abnormalities should enable development of new, effective therapeutic agents in the near future.
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