Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 111, Issue 2, Pages 641-643Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2000.02356.x
Keywords
congenital leukaemia; treatment; chemotherapy; transient leukaemia; t(8;16)
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Congenital leukaemia (CL) is a rare disorder that presents with extramedullary infiltrates and a myeloid phenotype. CL can progress rapidly without adequate treatment, but, paradoxically, may also remit spontaneously. Because of the significant toxicity involved in delivering chemotherapy to newborns, it is important to identify those newborns who may not require treatment. We describe an infant who presented at 1 week of age with congenital myeloid leukaemia. Cytogenetic analysis revealed a t(8;16)(q11;p13) translocation. The infant's leukaemia underwent a spontaneous regression. This case further confirms the possibility of spontaneous remission in congenital leukaemia. Moreover, it suggests that the presence of a clonal cytogenetic aberration does not preclude the possibility of a spontaneous regression in CL.
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