Journal
BIOFOULING
Volume 30, Issue 7, Pages 773-788Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2014.926475
Keywords
silver nanoparticles; PVA; endotracheal intubation; biofilm; endotracheal tube; antimicrobial
Funding
- NHMRC [571905]
- Australian Research Council [FT110100996]
- Australian Research Council [FT110100996] Funding Source: Australian Research Council
- National Health and Medical Research Council of Australia [571905] Funding Source: NHMRC
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Endotracheal intubation is commonly associated with hospital-acquired infections as the intubation device acts as reservoir for bacterial colonization in the lungs. To reduce the incidence of bacterial colonization on the tubes, hydrogel coatings loaded with antimicrobial agents are gaining popularity. The aim of this study was to incorporate silver nanoparticles (AgNPs) into polyvinyl alcohol (PVA) to form stable hydrogels. Embedding AgNPs into PVA resulted in a decreased elongation at break and an increased tensile strength compared to PVA alone. The Ag release profile varied as a function of the degree of hydrolysis of PVA: the higher degree of hydrolysis demonstrated a lower release rate. Fourier infrared transform spectroscopy demonstrated that AgNPs interacted exclusively with the -OH groups of PVA. AgNP-loaded PVA was non-toxic against human normal bronchial epithelial cells while effective against the attachment of Pseudomonas aeruginosa and Staphylococcus aureus with a greater effect on P. aeruginosa.
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