4.5 Article Proceedings Paper

Treatment of mild headache in disabled migraine sufferers: Results of the spectrum study

Journal

HEADACHE
Volume 40, Issue 10, Pages 792-797

Publisher

WILEY
DOI: 10.1046/j.1526-4610.2000.00144.x

Keywords

sumatriptan; spectrum; mild; migraine; disability

Ask authors/readers for more resources

Objective.-To evaluate the effectiveness of sumatriptan, 50-mg tablets, versus placebo for early intervention while head pain was mild in patients with disabling migraine. Methods.-A post hoc analysis was performed in a subgroup of patients from a large, randomized, placebo-controlled study of patients with disabling headache who treated while pain was mild. Pain-free response 2 and 4 hours postdose, headache recurrence, and safety were examined. Significance tests were performed only for the first-treated attacks. Results.-Twenty-six patients with disabling headache treated 46 mild and 166 moderate or severe headaches. For the first-treated headaches while pain was mild, pain-free rates were significantly higher for sumatriptan than placebo 4 hours postdose (78% versus 0%, P=.02), but not 2 hours postdose (52% versus 0%, P=.22), Across all headaches treated while pain was mild, pain-free responses were higher for sumatriptan than placebo 4 hours (85% versus 17%) and 2 hours (50% versus 0%) postdose compared with placebo, When the same patients treated headaches while pain was moderate or severe, pain-free rates were lower than that reported for treatment during mild pain. There was a trend toward lower headache recurrence in headaches treated while pain was mild compared with moderate or severe pain (13% versus 18%), No drug-related adverse events were reported in the headaches treated while pain was mild. Conclusions.-Patients with disabling migraine may benefit from early intervention with sumatriptan, 50 mg, while pain is mild.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available