Doppler-derived mitral deceleration time as an early predictor of left ventricular thrombus rafter first anterior acute myocardial infarction

Background The relation between left ventricular (LV) diastolic function and IV thrombus has not yet been fully investigated. The aim of this study was to determine whether early assessment of Doppler-derived mitral deceleration time (DT), a measure of IV compliance and filling, may predict LV thrombus formation after acute myocardial infarction. Methods and Results Two-dimensional and Doppler echocardiographic examinations were performed in 98 consecutive patients (aged 57 +/- 12 years; 8 women) with first acute myocardial infarction. The patients were studied within 24 hours and at days 3, 7 15, and 30 after arrival to the coronary care unit. Mitral flow velocities were obtained from the apical 4-chamber view with pulsed Doppler. IV thrombus was detected in 20 of 98. patients. Patients were divided into 2 groups according to LV thrombus formation: group 1 (n = 20) with thrombus and group 2 (n = 78) without thrombus. Mitral E-wave DT was significantly shorter in group 1 than group 2 (134 ms vs 175 ms; P < .001). Patients in group 1 had significantly larger LV end-diastolic and end-systolic volumes and a higher wall motion score index than patients in group 2 (133 +/- 39 mL vs 112 +/- 41 mL, P = .03; 83 +/- 34 mL vs 59 +/- 30 mL, P = .003; and 1.8 +/- 0.3 mL vs 1.5 +/- 0.3 mL, P = .007, respectively). The LV election fraction was significantly lower in group 1 than in group 2 (39% +/- 13% vs 48% +/- 12%, P = .004). In a multivariate regression analysis, mitral E-wave DT was identified as an independent variable related to development of LV thrombus (P = .04). Conclusions Doppler-derived mitral DT is superior to conventional clinical and 2-dimensional echocardiographic assessment in estimating the risk of left ventricular thrombosis after myocardial infarction.