Journal
ORGANIC LETTERS
Volume 2, Issue 22, Pages 3413-3416Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol006303f
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[GRAPHICS] An efficient and convenient synthetic strategy to redox-labeled C8-derivatives of 5'-deoxyadenosine is described, The Pd(0) cross-coupling chemistry is amenable to both oxidative and reductive redox probes. The corresponding phosphoramidites of phenothiazine and anthraquinone nucleosides are amenable to automated DNA synthesis. The resulting labeled oligodeoxynucleotide strands form stable B-form duplexes with melting temperatures and CD spectra similar to those of the unlabeled analogues.
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