Journal
SCIENCE
Volume 290, Issue 5493, Pages 995-997Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5493.995
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- NCI NIH HHS [CA47958] Funding Source: Medline
- NIGMS NIH HHS [GM24544] Funding Source: Medline
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The SpoIIIE protein of Bacillus subtilis is required for chromosome segregation during spore formation. The COOH-terminal cytoplasmic part of SpoIIIE was shown to be a DNA-dependent adenosine triphosphatase (ATPase) capable of tracking along DNA in the presence of ATP, and the NH2-terminal part of the protein was found to mediate its Localization to the division septum. Thus, during sporulation, SpoIIIE appears to act as a DNA pump that actively moves one of the replicated pair of chromosomes into the prespore. The presence of SpoIIIE homologs in a broad range of bacteria suggests that this mechanism for active transport of DNA may be widespread.
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