Journal
BIOFOULING
Volume 24, Issue 6, Pages 439-448Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927010802331829
Keywords
ampetoids; antibacterial; antimicrobial; polypeptoid; antifouling
Funding
- NIH [R37 DE014193, R01 AI072666, R01 EB003806]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072666] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806, R01EB005772] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R37DE014193] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE014193] Funding Source: NIH RePORTER
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Surface modification techniques that create surfaces capable of killing adherent bacteria are promising solutions to infections associated with implantable medical devices. Antimicrobial (AM) peptoid oligomers (ampetoids) that were designed to mimic helical AM peptides were synthesised with a peptoid spacer chain to allow mobility and an adhesive peptide moiety for easy and robust immobilisation onto substrata. TiO2 substrata were modified with the ampetoids and subsequently backfilled with an antifouling (AF) polypeptoid polymer in order to create polymer surface coatings composed of both AM (active) and AF (passive) peptoid functionalities. Confocal microscopy images showed that the membranes of adherent E. coli cells were damaged after 2-h exposure to the modified substrata, suggesting that ampetoids retain AM properties even when immobilised on substrata.
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