Journal
NEUROREPORT
Volume 11, Issue 16, Pages 3427-3430Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200011090-00005
Keywords
Chamorros; Guam; neurofibrillary lesions; spinal cord; tau epitopes
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We examined spinal cord sections from Guamanian Chamorros with or without amyotrophic lateral sclerosis or parkinsonism-dementia complex using immunohistochemistry and antibodies to epitopes that span the length of tau to characterize the tau epitope profile of neurofibrillary tangles in these spinal cords. Most:(16/20) spinal cords, including some from Chamorros without documented clinical disease, contained tangles with a tau epitope profile similar to the tangles found in the forebrain and brain stem of these patients. NeuroReport 11:3427-3430 (C) 2000 Lippincott Williams & Wilkins.
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