Journal
NATURE
Volume 408, Issue 6809, Pages 239-247Publisher
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/35041687
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Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
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