Journal
NEUROREPORT
Volume 11, Issue 16, Pages 3419-3422Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200011090-00003
Keywords
amyotrophic lateral sclerosis; cerebrospinal fluid; matrix-metalloproteinase-9; serum; tissue inhibitor of matrix metalloproteinase-I
Categories
Ask authors/readers for more resources
Matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), were analysed by enzyme-linked immunosorbent assay (ELISA) and by zymography in serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). In contrast to patients with inflammatory diseases, MMP-9 levels were not elevated in CSF of ALS patients. In serum, however, compared to healthy donors, MMP-9 was significantly (p=0.0003) increased up to levels as high as those of viral meningoencephalitis (VM) or bacterial meningitis. (BM) patients. MMP-9 levels remained elevated during long-term observation of ALS patients. In the absence of an inflammatory response, the results indicate that the increase of MMP-9 in serum of ALS patients might be caused by upregulation of MMP-9 in denervated muscles or in degenerating peripheral nerves following motor neurone loss. NeuroReport 11:3419-3422 (C) 2000 Lippincott Williams & Wilkins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available