Journal
CIRCULATION RESEARCH
Volume 87, Issue 10, Pages 840-844Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.87.10.840
Keywords
superoxide; nitric oxide; endothelium; NADH/NADPH oxidase; xanthine oxidase
Funding
- NHLBI NIH HHS [HL59243, HL58000, R0-1 HL39006] Funding Source: Medline
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Accumulating evidence suggests that oxidant stress alters many functions of the endothelium, including modulation of vasomotor tone. Inactivation of nitric oxide (NO.) by superoxide and other reactive oxygen species (ROS) seems to occur in conditions such as hypertension, hypercholesterolemia, diabetes, and cigarette smoking, Loss of NO. associated with these traditional risk factors may in part explain why they predispose to atherosclerosis. Among many enzymatic systems that are capable of producing ROS, xanthine oxidase, NADH/NADPH oxidase, and uncoupled endothelial nitric oxide synthase have been extensively studied in vascular cells. As the role of these various enzyme sources of ROS become clear, it will perhaps be possible to use more specific therapies to prevent their production and ultimately correct endothelial dysfunction.
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