Journal
NEUROLOGY
Volume 55, Issue 9, Pages 1396-1397Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.55.9.1396
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- NIA NIH HHS [AG03991, AG05681] Funding Source: Medline
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The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
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