Journal
NUCLEIC ACIDS RESEARCH
Volume 28, Issue 22, Pages 4474-4478Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/28.22.4474
Keywords
-
Categories
Funding
- NCI NIH HHS [P01 CA016519, CA16519] Funding Source: Medline
Ask authors/readers for more resources
Telomere length and telomerase activity directly affect-the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice, Telomere length :was considerably shorter in wild-derived strains than in the established strains, We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available