Journal
BIOFACTORS
Volume 35, Issue 4, Pages 332-337Publisher
WILEY
DOI: 10.1002/biof.46
Keywords
VEGF; vascular endothelial growth factor; angiogenesis; endothelial cell
Funding
- NEI NIH HHS [R01 EY015435] Funding Source: Medline
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Vascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration. This review details our current understanding of VEGF signaling and discusses the benefits and unexpected side effects of promising anti-angiogenic therapeutics that are currently being used to inhibit neovacularization in tumors.
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