Journal
JOURNAL OF NEUROSCIENCE
Volume 20, Issue 22, Pages 8443-8451Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.20-22-08443.2000
Keywords
basal ganglia; brain slices; dopamine; intracellular recordings; nitric oxide synthase-positive interneurons; phosphatases; protein kinase C; protein kinase G
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Funding
- NIDA NIH HHS [P01 DA010044, DA 10044] Funding Source: Medline
- NIMH NIH HHS [MH 40899, P01 MH040899] Funding Source: Medline
- Telethon [E.0729] Funding Source: Medline
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A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatal synapses on medium spiny neurons, we provide evidence that the D1-like receptor-dependent activation of DA and cyclic adenosine 3',5' monophosphate-regulated phosphoprotein 32 kDa is a crucial step for the induction of both long-term depression (LTD) and long-term potentiation (LTP), two opposing forms of synaptic plasticity. In addition, formation of LTD and LTP requires the activation of protein kinase G and protein kinase A, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations.
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