Serglycin proteoglycan: Regulating the storage and activities of hematopoietic proteases

Serglycin (SG), like all other proteoglycans, consists of a protein core to which sulfated and thereby negatively charged polysaccharide chains of glycosaminoglycan type are attached. The recent generation of mice lacking a functional SG gene has revealed a number of biological functions of SG. In particular, it has been shown that SG has a key role in promoting the storage and in regulating the activities of a number of proteases expressed in hematopoietic cell types, most notably various mast cell proteases. In this review, we summarize the recent development in our understanding of the biological function of SG, in particular by focusing on the novel insight provided through analysis of the SG-deficient mouse strain. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 61-68. E-mail: gunnar.pejler@afb.slu.se