Journal
JOURNAL OF IMMUNOLOGY
Volume 165, Issue 10, Pages 5664-5670Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.10.5664
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The mechanisms generating new alleles at the MHC loci are still unknown in detail, and several proposals have been made to explain the extent of polymorphism. The patchwork pattern of polymorphism in the 2nd exon of HLA-DRBI recommends this locus as a model for the study of the potential of interallelic gene conversion, In general, the inference of gene conversion-like events based exclusively on exon sequence comparisons may be misleading because the identity of the putative donor allele remains unknown. In this study, we describe five alleles of the HLA-DRBI gene, which intron regions give evidence for interlineage recombination events either strictly located at the 2nd exon or involving the adjacent Introns, Furthermore, we show that the noncoding regions provide important clues to the mechanisms of the generation of new alleles, and our results indicate that interlineage recombinations may be hidden and are perhaps more frequent than currently expected.
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