Journal
FEMS MICROBIOLOGY LETTERS
Volume 192, Issue 2, Pages 159-162Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2000.tb09375.x
Keywords
Mycobacterium; azole; bactericidal; cytochrome
Categories
Ask authors/readers for more resources
Azole antifungals are central to therapy and act by inhibiting a cytochrome P450, sterol 14-demethylase and blocking normal sterol synthesis. Our recent identification of a mycobacterial sterol biosynthetic pathway led us to probe the efficacy of a range of these compounds against Mycobacterium smegmatis. Several showed equivalent or greater inhibitory effects to those against Candida albicans, and bactericidal activity was demonstrated for four compounds, clotrimazole, econazole, miconazole and tebuconazole. The major drug used clinically, fluconazole, was ineffective. The results are discussed in the light of the world-wide spread of tuberculosis, including drug resistant Forms and the requirement For new drugs. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available