Journal
ORGANIC LETTERS
Volume 2, Issue 23, Pages 3743-3746Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0002830
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[GRAPHICS] A 10-step solid phase synthesis of the cytotoxic depsipeptide sansalvamide A (1) has been accomplished in an overall yield of 67% with >95% purity employing polymer-bound phenylalanine building block 2, Both the N- and C-termini of 2 are extended followed by on resin head-to-tail macrocyclization of the linear peptide in a high yield, This should be a general stategy for the synthesis of diverse libraries of cyclic peptides and depsipeptides that contain exclusively phenylalanine and other hydrophobic side chains.
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