Journal
ORGANIC LETTERS
Volume 2, Issue 23, Pages 3687-3689Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol000270m
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- NIGMS NIH HHS [GM36792] Funding Source: Medline
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[GRAPHICS] A strictly pair-selective synthesis of conjugated diynes via Pd-catalyzed cross coupling of 1,3-diynylzincs is described. This method, like the Cadiot-Chodkiewicz reaction, requires three steps for the synthesis of (RC)-C-1=CC=CR2 from (RC)-C-1=CH, (RX)-X-2, and HC=CH. However, the high pair-selectivity permitting high yield production of the desired conjugated diynes without separation of symmetrical diynes promises to make the present protocol superior to the Cadiot-Chodkiewicz reaction in many cases.
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