Journal
SCIENCE
Volume 290, Issue 5495, Pages 1347-1351Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5495.1347
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TNAs [(L)-alpha -threofuranosyl oligonucleotides] containing vicinally connected (3'-->2') phosphodiester bridges undergo informational base pairing in antiparallel strand orientation and are capable of cross-pairing with RNA and DNA. Being derived from a sugar containing only four carbons, TNA is structurally the simplest of all potentially natural oligonucleotide-type nucleic acid alternatives studied thus far. This, along with the base-pairing properties of TNA, warrants close scrutiny of the system in the context of the problem of RNA's origin.
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