Journal
SCIENCE
Volume 290, Issue 5495, Pages 1354-1357Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5495.1354
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Funding
- NIAID NIH HHS [AI42767, T32AI07511, AI36864] Funding Source: Medline
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T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8(+) T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8(+) T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8(+) T cell homeostasis independently of their role as antimicrobial effector molecules.
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