4.4 Article

ATP puts the brake on DNA double-strand break repair A new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

Rajashree A. Deshpande et al.

EMBO JOURNAL (2014)

Article Cell Biology

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

Ramon Roset et al.

GENES & DEVELOPMENT (2014)

Article Biochemistry & Molecular Biology

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Atsushi Shibata et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

Nodar Makharashvili et al.

MOLECULAR CELL (2014)

Article Immunology

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

Susanne Roth et al.

NATURE IMMUNOLOGY (2014)

Review Cell Biology

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Yosef Shiloh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET

Brian Cannon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

Takeshi Kondo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

Repair of Double-Strand Breaks by End Joining

Kishore K. Chiruvella et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Cell Biology

The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks

Alessia Balestrini et al.

CELL REPORTS (2013)

Article Biochemistry & Molecular Biology

The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair

Clara Correia Reis et al.

EMBO JOURNAL (2012)

Article Genetics & Heredity

Multiple Barriers to Nonhomologous DNA End Joining During Meiosis in Drosophila

Eric F. Joyce et al.

GENETICS (2012)

Article Biochemistry & Molecular Biology

ATP Hydrolysis by RAD50 Protein Switches MRE11 Enzyme from Endonuclease to Exonuclease

Jerzy Majka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Human Ku70/80 Protein Blocks Exonuclease 1-mediated DNA Resection in the Presence of Human Mre11 or Mre11/Rad50 Protein Complex

Jingxin Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Disruption of the Bacteriophage T4 Mre11 Dimer Interface Reveals a Two-state Mechanism for Exonuclease Activity

Dustin W. Albrecht et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

J. Ross Chapman et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling

Christian B. Schiller et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

Carolin Moeckel et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

Analysis of MRE11's function in the 5′→3′ processing of DNA double-strand breaks

Shuren Liao et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

Biochemical Characterization of Bacteriophage T4 Mre11-Rad50 Complex

Timothy J. Herdendorf et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

DNA Repair Factor MRE11/RAD50 Cleaves 3′-Phosphotyrosyl Bonds and Resects DNA to Repair Damage Caused by Topoisomerase 1 Poisons

Elizabeth J. Sacho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

Valerie Garcia et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

Marcel Hohl et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

Gareth J. Williams et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

Young Bong Park et al.

STRUCTURE (2011)

Article Biochemistry & Molecular Biology

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis

Elaine M. Taylor et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Multidisciplinary Sciences

ATM Activation by Oxidative Stress

Zhi Guo et al.

SCIENCE (2010)

Review Biology

Cellular radiosensitivity: How much better do we understand it?

Penny Jeggo et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Multiple functions of MRN in end-joining pathways during isotype class switching

Maria Dinkelmann et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

Anyong Xie et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Emilie Rass et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The P-furiosus Mre11/Rad50 Complex Promotes 5′ Strand Resection at a DNA Double-Strand Break

Ben B. Hopkins et al.

Article Biochemistry & Molecular Biology

Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair

R. Scott Williams et al.

Article Biochemistry & Molecular Biology

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

Zhu Zhu et al.

Article Biochemistry & Molecular Biology

SbcCD causes a double-strand break at a DNA palindrome in the Escherichia coli chromosome

John K. Eykelenboom et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

Eleni P. Mimitou et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

The DNA damage response: Ten years after

J. Wade Harper et al.

MOLECULAR CELL (2007)

Article Biochemistry & Molecular Biology

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

Bettina M. Lengsfeld et al.

MOLECULAR CELL (2007)

Article Multidisciplinary Sciences

Human CtIP promotes DNA end resection

Alessandro A. Sartori et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

ATMIN defines an NBS1-independent pathway of ATM signalling

Nnennaya Kanu et al.

EMBO JOURNAL (2007)

Article Cell Biology

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Elijahu Berkovich et al.

NATURE CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Shuhei Matsuoka et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Travis H. Stracker et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex

A Dupré et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends

M Clerici et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

F Moreno-Herrero et al.

NATURE (2005)

Article Multidisciplinary Sciences

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

MJ Neale et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1

ZS You et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Cell Biology

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

S Difilippantonio et al.

NATURE CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

The Rad50 hook domain is a critical determinant of Mre11 complex functions

JJW Wiltzius et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

J Falck et al.

NATURE (2005)

Article Multidisciplinary Sciences

Nibrin functions in Ig class-switch recombination

S Kracker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Delineation of the role of the Mre11 complex in class switch recombination

A Lähdesmäki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

JH Lee et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

The Rad50 signature motif: Essential to ATP binding and biological function

G Moncalian et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage

L Ciapponi et al.

CURRENT BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex

M de Jager et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

The Mre11 complex is required for ATM activation and the G2/M checkpoint

CT Carson et al.

EMBO JOURNAL (2003)

Article Multidisciplinary Sciences

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

L Zou et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1

CY Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP

M de Jager et al.

NUCLEIC ACIDS RESEARCH (2002)

Article Biochemistry & Molecular Biology

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

S Burma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

M de Jager et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

A DNA damage response pathway controlled by Tel1 and the Mre11 complex

T Usui et al.

MOLECULAR CELL (2001)

Review Cell Biology

The Mre11 complex and ATM: collaborating to navigate S phase

JHJ Petrini

CURRENT OPINION IN CELL BIOLOGY (2000)

Article Multidisciplinary Sciences

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

DS Lim et al.

NATURE (2000)

Article Genetics & Heredity

ATM-dependent phosphorylation of nibrin in response to radiation exposure

M Gatei et al.

NATURE GENETICS (2000)