Journal
BIOESSAYS
Volume 36, Issue 8, Pages 788-797Publisher
WILEY
DOI: 10.1002/bies.201400039
Keywords
cell fate; cerebral cortex; Fezf1; Fezf2; gene expression; neurogenesis; olfactory system
Categories
Funding
- California Institute of Regenerative Medicine [RN1-00530-01]
- NIMH [R01-MH094589]
- March of Dimes Foundation
Ask authors/readers for more resources
Fezf1 and Fezf2 are highly conserved transcription factors that were first identified by their specific expression in the anterior neuroepithelium of Xenopus and zebrafish embryos. These proteins share an N-terminal domain with homology to the canonical engrailed repressor motif and a C-terminal DNA binding domain containing six C2H2 zinc-finger repeats. Over a decade of study indicates that the Fez proteins play critical roles during nervous system development in species as diverse as fruit flies and mice. Herein we discuss recent progress in understanding the functions of Fezf1 and Fezf2 in neurogenesis and cell fate specification during mammalian nervous system development. Going forward we believe that efforts should focus on understanding how expression of these factors is precisely regulated, and on identifying target DNA sequences and interacting partners. Such knowledge may reveal the mechanisms by which Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available