Journal
ONCOGENE
Volume 19, Issue 49, Pages 5598-5605Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203855
Keywords
angiogenesis; endothelial cells; receptor tyrosine kinases; signal transduction; VEGF receptors; VEGF
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VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family, VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological angiogenesis. VEGF-C and VEGF-D, as ligands for VEGFR-3 are also capable of stimulating lymphangiogenesis and at least VEGF-C can enhance lymphatic metastasis, Recent studies have shown that missense mutations within the VEGFR3 tyrosine kinase domain are associated with human hereditary lymphedema, suggesting an important role for this receptor in the development of the lymphatic vasculature.
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