Journal
ONCOGENE
Volume 19, Issue 49, Pages 5558-5567Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203858
Keywords
PDGF; cell cycle progression; signal transduction
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A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent signaling events required for a proliferative response. One is an acute burst of signaling, which occurs immediately after growth factor stimulation and lasts for 30-60 min. The other occurs in a different time frame (8-12 h post stimulation), and involves activation of cyclin dependent kinases (Cdks), In addition to a general overview of growth factor-dependent signaling,,ve present our 'two wave' hypothesis for how signaling and cell cycle progression are linked.
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