Journal
BIOESSAYS
Volume 35, Issue 12, Pages 1093-1100Publisher
WILEY
DOI: 10.1002/bies.201300068
Keywords
differentiation; epidermis; lncRNA; melanoma; non-coding RNA; skin
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Long non-coding RNAs (lncRNAs) have recently gained increasing attention because of their crucial roles in gene regulatory processes. Functional studies using mammalian skin as a model system have revealed their role in controlling normal tissue homeostasis as well as the transition to a diseased state. Here, we describe how lncRNAs regulate differentiation to preserve an undifferentiated epidermal progenitor compartment, and to maintain a functional skin permeability barrier. Furthermore, we will reflect on recent work analyzing the impact of lncRNAs on the progression from normal epithelium to the development of skin disorders and cancer.
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