Journal
FEBS LETTERS
Volume 485, Issue 2-3, Pages 135-141Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02219-5
Keywords
TWEAK; WSL-1; TRAMP; death receptor; apoptosis
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WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis, TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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