Journal
BIOESSAYS
Volume 36, Issue 2, Pages 173-183Publisher
WILEY
DOI: 10.1002/bies.201300118
Keywords
Ca2+; channel; lysosome; NAADP; TPC
Categories
Funding
- Wellcome Trust [102828] Funding Source: Medline
Ask authors/readers for more resources
Much excitement surrounded the proposal that a family of endo-lysosomal channels, the two-pore channels (TPCs) were the long sought after targets of the Ca2+-mobilising messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, the role of TPCs in NAADP signalling may be more complex than originally envisaged. First, NAADP may not bind directly to TPCs but via an accessory protein. Second, two papers recently challenged the notion that TPCs are NAADP-regulated Ca2+ channels by suggesting that they are highly selective Na+ channels regulated by the lipid phosphatidylinositol 3,5-bisphosphate and by ATP. This paper aims critically to evaluate the evidence for TPCs as NAADP targets and to discuss how the new findings fit in with what we know about endo-lysosomal Ca2+ stores.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available