Journal
NEUROREPORT
Volume 11, Issue 17, Pages 3793-3798Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200011270-00040
Keywords
brain mapping; cingulate; congenital learned helplessness; cytochrome oxidase; depression; genetic model; metabolism; prefrontal
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Funding
- NINDS NIH HHS [R01 NS37755] Funding Source: Medline
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The validity of congenital helplessness as a genetic rat model for human depression was investigated in cortical regions of the rat brain thought to be analogous to those showing abnormalities in human neuroimaging studies. Cortex metabolism was analyzed using quantitative cytochrome oxidase histochemistry. Congenital helpless rats showed changes in frontal and cingulate regions comparable to those that have demonstrated metabolic differences in human depression. Significant metabolic decreases were found in dorsal frontal, medial orbital, and anterior cingulate, whereas a significant increase was found in infraradiata (subgenual) cingulate. The direction of these changes were the same as those seen in human studies. These findings support the validity of congenital helplessness as a model for human depression. NeuroReport 11:3793-3798 (C) 2000 Lippincott Williams & Wilkins.
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