Journal
NEUROREPORT
Volume 11, Issue 17, Pages 3835-3841Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200011270-00047
Keywords
attention; brain; cerebral blood flow; cognition; imaging; marijuana; positron emission tomography; THC
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Funding
- NIDA NIH HHS [DA10551] Funding Source: Medline
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The effects of smoking marijuana on cognition and brain function were assessed with PET using (H2O)-O-15. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (e.g. orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication. NeuroReport 11:3835-3841 (C) 2000 Lippincott Williams & Wilkins.
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