Journal
NEUROREPORT
Volume 11, Issue 17, Pages 3719-3723Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200011270-00026
Keywords
apoptosis; calmodulin; PEP-19; PC12
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Funding
- NINDS NIH HHS [NS33299] Funding Source: Medline
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PEP-19 is a calmodulin-regulatory protein found specifically within neurons, though cellular functions of this protein have not been determined. In an effort to define potential effects of PEP-19, PC12 cell lines expressing this protein were generated and subjected to apoptotic stimuli. As measured by LDH release, cell death in PEP-19 expressing cells was 2- to 5-fold less following u.v. irradiation, and 2- to 4-fold less following staurosporine treatment than controls. Additionally, PEP-19-expressing cells displayed decreased DNA ladder formation, chromatin condensation, and caspase activation following staurosporine treatment. Overall, these results demonstrate that PEP-19 can inhibit apoptotic processes in PC12 cells, suggesting a potential regulatory mechanism for pathways leading to cell death. NeuroReport 11:3719-3723 (C) 2000 Lippincott Williams & Wilkins.
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