Journal
BIOESSAYS
Volume 35, Issue 3, Pages 231-241Publisher
WILEY
DOI: 10.1002/bies.201200063
Keywords
myogenesis; PAX7; satellite cells; stem cells; therapy
Categories
Funding
- Canadian Institutes of Health Research
- Muscular Dystrophy Association
- National Institutes of Health
- Howard Hughes Medical Institute
- Canadian Stem Cell Network
- Canada Research Chair Program
- Swiss National Science Foundation
- Ontario Research Fund
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Cell-based therapies for degenerative diseases of the musculature remain on the verge of feasibility. Myogenic cells are relatively abundant, accessible, and typically harbor significant proliferative potential ex vivo. However, their use for therapeutic intervention is limited due to several critical aspects of their complex biology. Recent insights based on mouse models have advanced our understanding of the molecular mechanisms controlling the function of myogenic progenitors significantly. Moreover, the discovery of atypical myogenic cell types with the ability to cross the blood-muscle barrier has opened exciting new therapeutic avenues. In this paper, we outline the major problems that are currently associated with the manipulation of myogenic cells and discuss promising strategies to overcome these obstacles.
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