Journal
BIOESSAYS
Volume 34, Issue 10, Pages 901-913Publisher
WILEY
DOI: 10.1002/bies.201200076
Keywords
chromatin; epigenetics; mathematical modelling; quantification; rate constants
Categories
Funding
- FP7 Network of Excellence EpiGeneSys
- Portuguese Science Foundation [SFRH/BD/40389/2007]
- Austrian Academy of Sciences
- Fundação para a Ciência e a Tecnologia [SFRH/BD/40389/2007] Funding Source: FCT
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How fast? How strong? How many? So what? Why do numbers matter in biology? Chromatin binding proteins are forever in motion, exchanging rapidly between bound and free pools. How do regulatory systems whose components are in constant flux ensure stability and flexibility? This review explores the application of quantitative and mathematical approaches to mechanisms of epigenetic regulation. We discuss methods for measuring kinetic parameters and protein quantities in living cells, and explore the insights that have been gained by quantifying and modelling dynamics of chromatin binding proteins.
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