Journal
BIOESSAYS
Volume 33, Issue 10, Pages 737-741Publisher
WILEY
DOI: 10.1002/bies.201100076
Keywords
blood brain barrier; dendritic cells; exosomes; RNAi; stem cells
Categories
Funding
- Medical Research Council [G0900887] Funding Source: researchfish
- Parkinson's UK [G-0904] Funding Source: researchfish
- Medical Research Council [G0900887] Funding Source: Medline
- Parkinson's UK [G-0904, G-1109] Funding Source: Medline
- MRC [G0900887] Funding Source: UKRI
Ask authors/readers for more resources
The demonstration that dendritic cell (DC)-derived exosomes can be exploited for targeted RNAi delivery to the brain after systemic injection provides the first proof-of-concept for the potential of these naturally occurring vesicles as vehicles of drug delivery. As well as being amenable to existing in vivo targeting strategies already in use for viruses and liposomes, this novel approach offers the added advantages of in vivo safety and low immunogenicity. Fulfilment of the potential of exosome delivery methods warrants a better understanding of their biology, as well as the development of novel production, characterisation, targeting and cargo-loading nanotechnologies. Ultimately, exosome-mediated drug delivery promises to overcome important challenges in the field of therapeutics, such as delivery of drugs across otherwise impermeable biological barriers, such as the blood brain barrier, and using patient-derived tissue as a source of individualised and biocompatible therapeutic drug delivery vehicles.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available