Journal
MECHANISMS OF DEVELOPMENT
Volume 99, Issue 1-2, Pages 65-70Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00476-7
Keywords
Xsox17; sox; endoderm; cell lineage; gut development; Xenopus
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Many molecules induce the ectopic expression of tissue-specific genes in Xenopus embryos. Conversely, interfering with their activity disrupts patterns of gene expression, implicating them in normal development. Does this mean that they control cell fate (i.e. position, as well as differentiation)? Xsox17 alpha and beta can induce ectopic expression of endodermal markers; inhibiting their function suppresses expression of endodermal marker genes in the developing gut (Cell 91 (1997) 397). Here we show the effect of these manipulations on cell lineage. Expressing Xsox17 in a cells normally fated to become ectoderm causes their descendants either to relocate into the embryonic gut or to die at a late developmental stage. Conversely, disrupting Xsox17 activity in cells normally fated to be endodermal causes them to enter mesodermal and ectodermal lineages. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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