Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 20, Issue 12, Pages 1039-1047Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/107999000750053690
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Although interferon-alpha (IFN-alpha) was discovered over 40 years ago, it was many years before it was registered as a therapeutic agent. Because of its unique qualities, it has been registered for both antiviral and antitumor indications. In addition to its therapeutic effects in viral diseases and cancer, IFN-alpha interferes with several important physiologic systems, It interacts with the immune system and affects several neuroendocrine and metabolic circuits. The specific mechanisms by which IFN-alpha exerts its therapeutic effects are complex, and it is very difficult to tie the biologic actions of IFN-alpha to specific clinical effects.
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