Journal
BIOESSAYS
Volume 32, Issue 12, Pages 1050-1057Publisher
WILEY-BLACKWELL
DOI: 10.1002/bies.201000081
Keywords
evolution; mitochondria; polypeptide tunnel exit; respiratory chain assembly; ribosome
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Funding
- Deutscher Akademischer Austausch Dienst (DAAD)
- Stiftung Rheinland-Pfalz fur Innovation
- Rheinland-Pfalz research initiative membrane transport
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The ribosomal polypeptide tunnel exit is the site where a variety of factors interact with newly synthesized proteins to guide them through the early steps of their biogenesis. In mitochondrial ribosomes, this site has been considerably modified in the course of evolution. In contrast to all other translation systems, mitochondrial ribosomes are responsible for the synthesis of only a few hydrophobic membrane proteins that are essential subunits of the mitochondrial respiratory chain. Membrane insertion of these proteins occurs co-translationally and is connected to a sophisticated assembly process that not only includes the assembly of the different subunits but also the acquisition of redox co-factors. Here, we describe how mitochondrial translation is organized in the context of respiratory chain assembly and speculate how alteration of the ribosomal tunnel exit might allow the establishment of a subset of specialized ribosomes that individually organize the early steps in the biogenesis of distinct mitochondrially-encoded proteins.
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