Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 33, Issue 12, Pages 849-858Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar990165g
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R29 GM54348] Funding Source: Medline
Ask authors/readers for more resources
Rotation about the C-N bond in amides can be catalyzed by Bronsted and Lewis acids, as well as nucleophiles and bases. Catalysis of amide isomerization occurs in biological systems via rotamase enzymes; however, the mechanisms by which these proteins operate are not completely understood. We outline investigations that provide experimental support for mechanisms believed to be feasible for the catalysis of amide isomerization and present practical applications that have resulted from this work.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available