Journal
NATURE REVIEWS GENETICS
Volume 1, Issue 3, Pages 171-181Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35042039
Keywords
-
Categories
Funding
- NICHD NIH HHS [R37 HD021502, R37 HD021502-14] Funding Source: Medline
Ask authors/readers for more resources
Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available