Journal
BIOESSAYS
Volume 31, Issue 5, Pages 492-495Publisher
WILEY
DOI: 10.1002/bies.200900005
Keywords
Akt; apoptosis; oncogenes; oxidative stress; senescence
Categories
Funding
- DFG [SFB 773, GRK 1302]
- Deutsche Krebshilfe
- Comprehensive Cancer Center Tubingen
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Akt, a protein kinase hyperactivated in many tumors, plays a major role in both cell survival and resistance to tumor therapy. A recent study,((1)) along with other evidences, shows interestingly, that Akt is not a single-function kinase, but may facilitate rather than inhibit cell death under certain conditions. This hitherto undetected function of Akt is accomplished by its ability to increase reactive oxygen species and to suppress antioxidant enzymes. The ability of Akt to down-regulate antioxidant defenses uncovers a novel Achilles' heel, which could be exploited by oxidant therapies in order to selectively eradicate tumor cells that express high levels of Akt activity.
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