Journal
BIOESSAYS
Volume 31, Issue 4, Pages 370-377Publisher
WILEY-BLACKWELL
DOI: 10.1002/bies.200800158
Keywords
heat shock proteins; human; molecular chaperones; mouse; stem cells
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Funding
- National Research Foundation
- Royal Society
- Innovation Fund
- The Claude Leon Foundation
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Self-renewal and differentiation of stem cells are tightly regulated processes subject to intrinsic and extrinsic signals. Molecular chaperones and co-chaperones, especially heat shock proteins (Hsp), are ubiquitous molecules involved in the modulation of protein conformational and complexation states. The function of Hsp, which are typically associated with stress response and tolerance, is well characterized in differentiated cells, while their role in stem cells remains unclear. It appears that embryonic stem cells exhibit increased stress tolerance and concomitant high levels of chaperone expression. This review critically evaluates stem cell research from a molecular chaperone perspective. Furthermore, we propose a model of chaperone-modulated self-renewal in mouse embryonic stem cells.
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