Journal
BIOESSAYS
Volume 30, Issue 6, Pages 542-555Publisher
WILEY
DOI: 10.1002/bies.20769
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI042236, R01 AI049561, R01 AI049561-16, R01 AI042236-10] Funding Source: Medline
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Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes and transitions through cell cycle phases in eukaryotic cells. This review focuses on the properties and functions of positive feedback in biological systems, including bistability, hysteresis and activation surges.
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